NovoLog® Mix 70/30 FlexPen®

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Other Delivery Systems

The 10-mL vial

NovoLog® Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, [rDNA origin]) is also available in 10-mL vials. Syringes are sold separately and may need a prescription from your doctor.

If you have questions about how to use the vial and syringe, see the Instructions for Use below or ask your healthcare provider.

NovoLog® Mix 70/30 10 mL vial (100 Units/mL, U-100) Instructions for Use

Read the following Patient Instructions for Use carefully before you start using your NovoLog® Mix 70/30 10 mL vial. Before starting, gather all of the supplies that you will need to use for preparing and giving your insulin injection.

Never re-use syringes and needles.

How should I use the NovoLog® Mix 70/30 (70% insulin aspart protamine suspension and 30% insulin aspart injection, [rDNA origin]) vial?

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  1. Check to make sure that you have the correct type of insulin. This is especially important if you use different types of insulin.
  2. Look at the vial and the insulin. The insulin should be white and cloudy after mixing. The tamper-resistant cap should be on the vial before the first use. If the cap has already been removed before your first use of the vial, or the insulin looks clear or contains particles, do not use it and return it to your pharmacy.
  3. Wash your hands with soap and water. Clean your injection site with an alcohol swab and let the injection site dry before you inject. Talk with your healthcare provider about how to rotate injection sites and how to give an injection.
  4. If you are using a new vial, pull off the tamper-resistant cap. Wipe the rubber stopper with an alcohol swab.
  5. Roll the vial gently 10 times in your hands to mix it. This should be done with the vial in a horizontal (flat) position between your palms. Do not shake the vial. Shaking right before the dose is drawn into the syringe may cause bubbles or foam. This can cause you to draw up the wrong dose of insulin. The insulin should be used only if it looks white and cloudy.
  6. Pull back the plunger on the syringe until the black tip reaches the marking for the number of units you will inject.
  7. Push the needle through the rubber stopper of the vial, and push the plunger all the way in to force air into the vial.
  8. Turn the vial and syringe upside down and slowly pull the plunger back to a few units beyond the correct dose needed.
  9. If there are any air bubbles, tap the syringe gently with your finger to raise the air bubbles to the top. Slowly push the plunger to the marking for your dose. This should move any air bubbles in the syringe back into the vial.
  10. Check to make sure you have the right dose of NovoLog® Mix 70/30 in the syringe.
  11. Pull the syringe out of the vial's rubber stopper.
  12. If there is a delay after you rolled the vial, you will have to roll it again to remix the insulin and redraw your medicine. Your healthcare provider should tell you if you need to pinch the skin before inserting the needle. This can be different from person to person so it is important to ask your healthcare provider if you did not receive instructions on pinching the skin. Insert the needle into the skin right away. Press the plunger to inject the insulin under your skin. Keep the needle under your skin for at least 6 seconds to make sure you have injected all the insulin. When you are finished injecting the insulin, pull the needle out of your skin.
  13. You may see a drop of NovoLog® Mix 70/30 at the needle tip. This is normal and has no effect on the dose you just received. If blood appears after you pull the needle from your skin, press the injection site lightly with an alcohol swab. Do not rub the area. Do not recap the needle.
  14. After the injection, dispose of the needle and syringe in a puncture-resistant container. Place used syringes, needles and insulin vials in a disposable puncture-resistant sharps container, or some type of hard plastic or metal container with a screw on cap such as a detergent bottle or coffee can.
  15. Ask your healthcare provider about the right way to throw away used syringes and needles. There may be state or local laws about the right way to throw away used syringes and needles. Do not throw away used needles and syringes in household trash or recycling bins.

Selected Important Safety Information

What are the possible side effects of NovoLog® Mix 70/30?

• Low blood sugar, including when too much is taken. Some symptoms include sweating, shakiness, confusion, and headache. Severe low blood sugar can cause unconsciousness, seizures, and death.

• Other side effects include low potassium in your blood, injection site reactions (like redness, swelling, and itching), skin thickening or pits at the injection site, weight gain, swelling of your hands and feet, if taken with thiazolidinediones (TZDs) possible heart failure, and vision changes.

Please click here for additional Important Safety Information